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UBE1C Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TBC4
Clone Names 2112202
Peptide ID 2112202
Additional Information
Gene ID 9039
Other Names NEDD8-activating enzyme E1 catalytic subunit, 632-, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3, UBA3, UBE1C
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1063b was selected from the C-term region of human UBE1C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBA3
Synonyms UBE1C
Function Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.


Bohnsack, R.N., et al., J. Biol. Chem. 278(29):26823-26830 (2003).Walden, H., et al., Nature 422(6929):330-334 (2003).Gong, L., et al., J. Biol. Chem. 274(17):12036-12042 (1999).Gubin, A.N., et al., Genomics 59(2):168-177 (1999).Osaka, F., et al., Genes Dev. 12(15):2263-2268 (1998).

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$ 80.00
Cat# BP1063b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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