|Other Names||DnaJ homolog subfamily B member 8, DNAJB8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins.|
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Provided below are standard protocols that you may find useful for product applications.
DNAJB8 belongs to the evolutionarily conserved DNAJ/HSP40family of proteins, which regulate molecular chaperone activity bystimulating ATPase activity. DNAJ proteins may have up to 3distinct domains: a conserved 70-amino acid J domain, usually atthe N terminus; a glycine/phenylalanine (G/F)-rich region; and acysteine-rich domain containing 4 motifs resembling a zinc fingerdomain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied byOMIM].
Hageman, J., et al. Mol. Cell 37(3):355-369(2010)Lamesch, P., et al. Genomics 89(3):307-315(2007)Ohtsuka, K., et al. Cell Stress Chaperones 5(2):98-112(2000)
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