Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SCN1B Antibody (N-Term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q07699 |
|---|---|
| Other Accession | NP_950238.1, NP_001028.1 |
| Clone Names | 91023133 |
| Gene ID | 6324 |
|---|---|
| Other Names | Sodium channel subunit beta-1, SCN1B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SCN1B |
|---|---|
| Function | Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:P97952} Cell projection {ECO:0000250|UniProtKB:P97952}. Cell projection, axon {ECO:0000250|UniProtKB:Q00954}. Note=Detected at nodes of Ranvier on the sciatic nerve. {ECO:0000250|UniProtKB:Q00954} |
| Tissue Location | The overall expression of isoform 1 and isoform 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver, kidney and pancreas. In brain, isoform 2 is most abundant in the cerebellum, followed by the cerebral cortex and occipital lobe, while isoform 1 levels are higher in the cortex compared to the cerebellum Isoform 2 is expressed in many regions of the brain, including cerebellar Purkinje cells, cortex pyramidal neurons and many of the neuronal fibers throughout the brain (at protein level). Also detected in dorsal root ganglion, in fibers of the spinal nerve and in cortical neurons and their processes (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Voltage-gated sodium channels are heteromeric proteinsthat function in the generation and propagation of actionpotentials in muscle and neuronal cells. They are composed of onealpha and two beta subunits, where the alpha subunit provideschannel activity and the beta-1 subunit modulates the kinetics ofchannel inactivation. SCN1B encodes a sodium channel beta-1subunit. Mutations in this gene result in generalized epilepsy withfebrile seizures plus, Brugada syndrome 5, and defects in cardiacconduction. Multiple transcript variants encoding differentisoforms have been found for this gene.
References
Grover, S., et al. Pharmacogenomics 11(7):927-941(2010)Tan, B.H., et al. Heart Rhythm 7(6):771-778(2010)Casini, S., et al. Cardiovasc. Res. 85(4):691-700(2010)Ogawa, R., et al. Int J Clin Pharmacol Ther 48(2):109-119(2010)Watanabe, H., et al. Circ Arrhythm Electrophysiol 2(3):268-275(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
