BHLHA15 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q7RTS1 |
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Other Accession | NP_803238.1 |
Clone Names | 100623331 |
Gene ID | 168620 |
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Other Names | Class A basic helix-loop-helix protein 15, bHLHa15, Class B basic helix-loop-helix protein 8, bHLHb8, Muscle, intestine and stomach expression 1, MIST-1, BHLHA15, BHLHB8, MIST1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | BHLHA15 |
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Synonyms | BHLHB8, MIST1 |
Function | Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | Expressed in brain, liver, spleen and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
References
Smits, K.M., et al. Ann Epidemiol 20(5):401-404(2010)Tian, X., et al. Mol. Cell. Biol. 30(5):1269-1284(2010)Stevens, J.D., et al. Differentiation 76(9):1006-1022(2008)Zhao, Y., et al. Mol. Endocrinol. 20(9):2187-2198(2006)McLellan, A.S., et al. Mech. Dev. 119 SUPPL 1, S285-S291 (2002) :
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