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BHLHA15 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q7RTS1
Other Accession NP_803238.1
Clone Names 100623331
Peptide ID 100623331
Additional Information
Gene ID 168620
Other Names Class A basic helix-loop-helix protein 15, bHLHa15, Class B basic helix-loop-helix protein 8, bHLHb8, Muscle, intestine and stomach expression 1, MIST-1, BHLHA15, BHLHB8, MIST1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BHLHA15
Synonyms BHLHB8, MIST1
Function Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3' (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in brain, liver, spleen and skeletal muscle.
Research Areas
Citations (0)

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Background

Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).

References

Smits, K.M., et al. Ann Epidemiol 20(5):401-404(2010)Tian, X., et al. Mol. Cell. Biol. 30(5):1269-1284(2010)Stevens, J.D., et al. Differentiation 76(9):1006-1022(2008)Zhao, Y., et al. Mol. Endocrinol. 20(9):2187-2198(2006)McLellan, A.S., et al. Mech. Dev. 119 SUPPL 1, S285-S291 (2002) :

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$ 80.00
Cat# BP10649b
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