|Other Names||Rho GTPase-activating protein 44, NPC-A-10, Rho-type GTPase-activating protein RICH2, RhoGAP interacting with CIP4 homologs protein 2, RICH-2, ARHGAP44, KIAA0672, RICH2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP- bound states. May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in association with SHANK3, is involved in synaptic plasticity. Promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation.|
|Cellular Location||Cell projection, dendritic spine. Recycling endosome. Cell junction, synapse. Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites.|
|Tissue Location||Highly expressed in brain. Expressed at weak level in other tissues.|
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Provided below are standard protocols that you may find useful for product applications.
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1.
Rollason, R., et al. J. Cell Biol. 184(5):721-736(2009)Richnau, N., et al. J. Biol. Chem. 276(37):35060-35070(2001)
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