ASL Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P04424 |
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Other Accession | NP_001020114.1, NP_000039.2 |
Clone Names | 90121070 |
Gene ID | 435 |
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Other Names | Argininosuccinate lyase, ASAL, Arginosuccinase, ASL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ASL |
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Function | Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (PubMed:11747433, PubMed:11747432, PubMed:9045711, PubMed:22081021, PubMed:2263616). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L- arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021). |
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Provided below are standard protocols that you may find useful for product applications.
Background
ASL encodes a member of the lyase 1 family. Theencoded protein forms a cytosolic homotetramer and primarilycatalyzes the reversible hydrolytic cleavage of argininosuccinateinto arginine and fumarate, an essential step in the liver indetoxifying ammonia via the urea cycle. Mutations in this generesult in the autosomal recessive disorder argininosuccinicaciduria, or argininosuccinic acid lyase deficiency. Anontranscribed pseudogene is also located on the long arm ofchromosome 22. Alternatively spliced transcript variants encodingdifferent isoforms have been described.
References
Hozyasz, K.K., et al. Arch. Oral Biol. (2010) In press :Trevisson, E., et al. J. Biol. Chem. 284(42):28926-28934(2009)Trevisson, E., et al. Hum. Mutat. 28(7):694-702(2007)Tanaka, T., et al. Tohoku J. Exp. Med. 198(2):119-124(2002)Kleijer, W.J., et al. J. Inherit. Metab. Dis. 25(5):399-410(2002)
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