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C2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P06681
Clone Names 80411132
Peptide ID 80411132
Additional Information
Gene ID 717
Other Names Complement C2, C3/C5 convertase, Complement C2b fragment, Complement C2a fragment, C2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name C2
Function Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
Cellular Location Secreted.
Research Areas
Citations (0)

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Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. ActivatedC1 cleaves C2 into C2a and C2b. The serine proteinase C2a thencombines with complement factor 4b to create the C3 or C5convertase. Deficiency of C2 has been reported to associated withcertain autoimmune diseases and SNPs in this gene have beenassociated with altered susceptibility to age-related maculardegeneration. This gene localizes within the class III region ofthe MHC on the short arm of chromosome 6. Alternative splicingresults in multiple transcript variants encoding distinct isoforms.Additional transcript variants have been described in publicationsbut their full-length sequence has not been determined.


Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Liu, X., et al. Retina (Philadelphia, Pa.) 30(8):1177-1184(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Ishii, Y., et al. J. Immunol. 151(1):170-174(1993)

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$ 80.00
Cat# BP10662a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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