|Other Names||Fanconi anemia group J protein, Protein FACJ, ATP-dependent RNA helicase BRIP1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein C-terminal helicase 1, BRCA1-interacting protein 1, BRIP1, BACH1, FANCJ|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.|
|Tissue Location||Ubiquitously expressed, with highest levels in testis.|
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Provided below are standard protocols that you may find useful for product applications.
BRIP1 is a member of the RecQDEAH helicase family and interacts with the BRCT repeats of breastcancer, type 1 (BRCA1). The bound complex is important in thenormal double-strand break repair function of breast cancer, type 1(BRCA1).
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Bailey, S.D., et al. Diabetes Care (2010) In press :Solyom, S., et al. Fam. Cancer (2010) In press :Xie, J., et al. Oncogene 29(17):2499-2508(2010)Smith, I.M., et al. ORL J. Otorhinolaryngol. Relat. Spec. 72(1):44-50(2010)
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