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BRIP1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BX63 |
|---|---|
| Clone Names | 80722047 |
| Gene ID | 83990 |
|---|---|
| Other Names | Fanconi anemia group J protein, Protein FACJ, ATP-dependent RNA helicase BRIP1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein C-terminal helicase 1, BRCA1-interacting protein 1, BRIP1, BACH1, FANCJ |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BRIP1 (HGNC:20473) |
|---|---|
| Function | DNA-dependent helicase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA- protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Ubiquitously expressed, with highest levels in testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
BRIP1 is a member of the RecQDEAH helicase family and interacts with the BRCT repeats of breastcancer, type 1 (BRCA1). The bound complex is important in thenormal double-strand break repair function of breast cancer, type 1(BRCA1).
References
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Bailey, S.D., et al. Diabetes Care (2010) In press :Solyom, S., et al. Fam. Cancer (2010) In press :Xie, J., et al. Oncogene 29(17):2499-2508(2010)Smith, I.M., et al. ORL J. Otorhinolaryngol. Relat. Spec. 72(1):44-50(2010)
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