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ACF Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9NQ94
Clone Names 81201001
Peptide ID 81201001
Additional Information
Gene ID 29974
Other Names APOBEC1 complementation factor, APOBEC1-stimulating protein, A1CF, ACF, ASP {ECO:0000312|EMBL:CAB947541}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name A1CF
Synonyms ACF, ASP {ECO:0000312|EMBL:CAB94754.1}
Function Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
Cellular Location Nucleus. Endoplasmic reticulum. Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity) Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.
Tissue Location Widely expressed with highest levels in brain, liver, pancreas, colon and spleen.
Research Areas
Citations (0)

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Mammalian apolipoprotein B mRNA undergoes site-specific Cto U deamination, which is mediated by a multi-component enzymecomplex containing a minimal core composed of APOBEC-1 and acomplementation factor encoded by this gene. The gene product hasthree non-identical RNA recognition motifs and belongs to the hnRNPR family of RNA-binding proteins. It has been proposed that thiscomplementation factor functions as an RNA-binding subunit anddocks APOBEC-1 to deaminate the upstream cytidine. Studies suggestthat the protein may also be involved in other RNA editing or RNAprocessing events.


Galloway, C.A., et al. Biochem. Biophys. Res. Commun. 391(1):659-663(2010)Blanc, V., et al. Mol. Cell. Biol. 25(16):7260-7269(2005)Deloukas, P., et al. Nature 429(6990):375-381(2004)Xie, K., et al. Proc. Natl. Acad. Sci. U.S.A. 101(21):8114-8119(2004)Blanc, V., et al. J. Biol. Chem. 278(42):41198-41204(2003)

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$ 80.00
Cat# BP10670b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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