YWHAE Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P62258 |
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Clone Names | 90121052 |
Gene ID | 7531 |
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Other Names | 14-3-3 protein epsilon, 14-3-3E, YWHAE |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | YWHAE |
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Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). |
Cellular Location | Nucleus. Cytoplasm Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
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Provided below are standard protocols that you may find useful for product applications.
Background
YWHAE belongs to the 14-3-3 family of proteinswhich mediate signal transduction by binding tophosphoserine-containing proteins. This highly conserved proteinfamily is found in both plants and mammals, and this protein is100% identical to the mouse ortholog. It interacts with CDC25phosphatases, RAF1 and IRS1 proteins, suggesting its role indiverse biochemical activities related to signal transduction, suchas cell division and regulation of insulin sensitivity. It has alsobeen implicated in the pathogenesis of small cell lung cancer.
References
Zuo, S., et al. J. Proteome Res. 9(7):3465-3478(2010)Liu, Y., et al. Brain Res. 1336, 98-102 (2010) :Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Han, D., et al. Biochem. Biophys. Res. Commun. 396(2):401-406(2010)Che, X.H., et al. BMC Cancer 10, 306 (2010) :
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