|Other Names||14-3-3 protein epsilon, 14-3-3E, YWHAE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.|
|Cellular Location||Cytoplasm. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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YWHAE belongs to the 14-3-3 family of proteinswhich mediate signal transduction by binding tophosphoserine-containing proteins. This highly conserved proteinfamily is found in both plants and mammals, and this protein is100% identical to the mouse ortholog. It interacts with CDC25phosphatases, RAF1 and IRS1 proteins, suggesting its role indiverse biochemical activities related to signal transduction, suchas cell division and regulation of insulin sensitivity. It has alsobeen implicated in the pathogenesis of small cell lung cancer.
Zuo, S., et al. J. Proteome Res. 9(7):3465-3478(2010)Liu, Y., et al. Brain Res. 1336, 98-102 (2010) :Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Han, D., et al. Biochem. Biophys. Res. Commun. 396(2):401-406(2010)Che, X.H., et al. BMC Cancer 10, 306 (2010) :
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