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SREBF2 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q12772
Clone Names 90504159
Peptide ID 90504159
Additional Information
Gene ID 6721
Other Names Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2, SREBF2, BHLHD2, SREBP2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BHLHD2, SREBP2
Function Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols
Tissue Location Ubiquitously expressed in adult and fetal tissues
Research Areas
Citations (0)

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This gene encodes a ubiquitously expressed transcriptionfactor that controls cholesterol homeostasis by stimulatingtranscription of sterol-regulated genes. The encoded proteincontains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.


Gerin, I., et al. J. Biol. Chem. 285(44):33652-33661(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Marquart, T.J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(27):12228-12232(2010)Najafi-Shoushtari, S.H., et al. Science 328(5985):1566-1569(2010)Pramfalk, C., et al. J. Lipid Res. 51(6):1354-1362(2010)

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$ 80.00
Cat# BP10673c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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