|Other Names||Sterol regulatory element-binding protein 2, SREBP-2, Class D basic helix-loop-helix protein 2, bHLHd2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2, SREBF2, BHLHD2, SREBP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols|
|Tissue Location||Ubiquitously expressed in adult and fetal tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a ubiquitously expressed transcriptionfactor that controls cholesterol homeostasis by stimulatingtranscription of sterol-regulated genes. The encoded proteincontains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
Gerin, I., et al. J. Biol. Chem. 285(44):33652-33661(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Marquart, T.J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(27):12228-12232(2010)Najafi-Shoushtari, S.H., et al. Science 328(5985):1566-1569(2010)Pramfalk, C., et al. J. Lipid Res. 51(6):1354-1362(2010)
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