|Other Names||cAMP-specific 3', 5'-cyclic phosphodiesterase 7B, PDE7B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.|
|Tissue Location||Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The 3',5'-cyclic nucleotides cAMP and cGMP function assecond messengers in a wide variety of signal transductionpathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs)catalyze the hydrolysis of cAMP and cGMP to the corresponding5'-monophosphates and provide a mechanism to downregulate cAMP andcGMP signaling. This gene encodes a cAMP-specificphosphodiesterase, a member of the cyclic nucleotidephosphodiesterase family.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kestenbaum, B., et al. J. Am. Soc. Nephrol. 21(7):1223-1232(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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