|Other Names||Protein phosphatase 1 regulatory subunit 3A, Protein phosphatase 1 glycogen-associated regulatory subunit, Protein phosphatase type-1 glycogen targeting subunit, RG1, PPP1R3A, PP1G|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity).|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Skeletal muscle and heart.|
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The glycogen-associated form of protein phosphatase-1(PP1) derived from skeletal muscle is a heterodimer composed of a37-kD catalytic subunit and a 124-kD targeting and regulatorysubunit. This gene encodes the regulatory subunit which binds tomuscle glycogen with high affinity, thereby enhancingdephosphorylation of glycogen-bound substrates for PP1 such asglycogen synthase and glycogen phosphorylase kinase. [provided byRefSeq].
Yoshida, T., et al. Int. J. Mol. Med. 24(2):233-246(2009)Yoshida, T., et al. Genomics 93(3):221-226(2009)Gieger, C., et al. PLoS Genet. 4 (11), E1000282 (2008) :Savage, D.B., et al. PLoS Med. 5 (1), E27 (2008) :Olsen, J.V., et al. Cell 127(3):635-648(2006)
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