|Other Names||Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component(1-203), APCS, PTX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.|
|Tissue Location||Found in serum and urine.|
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The protein encoded by this gene is a glycoprotein,belonging to the pentraxin family of proteins, which has acharacteristic pentameric organization. These family members haveconsiderable sequence homology which is thought to be the result ofgene duplication. The binding of the encoded protein to proteins inthe pathological amyloid cross-beta fold suggests its possible roleas a chaperone. This protein is also thought to control thedegradation of chromatin. It has been demonstrated that thisprotein binds to apoptotic cells at an early stage, which raisesthe possibility that it is involved in dealing with apoptotic cellsin vivo.
Song, Z., et al. Atherosclerosis 211(1):90-95(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Lu, J., et al. Nature 456(7224):989-992(2008)Verwey, N.A., et al. Dement Geriatr Cogn Disord 26(6):522-527(2008)
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