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APCS Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P02743
Clone Names 90713007
Peptide ID 90713007
Additional Information
Gene ID 325
Other Names Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component(1-203), APCS, PTX2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name APCS
Synonyms PTX2
Function Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
Cellular Location Secreted.
Tissue Location Found in serum and urine.
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a glycoprotein,belonging to the pentraxin family of proteins, which has acharacteristic pentameric organization. These family members haveconsiderable sequence homology which is thought to be the result ofgene duplication. The binding of the encoded protein to proteins inthe pathological amyloid cross-beta fold suggests its possible roleas a chaperone. This protein is also thought to control thedegradation of chromatin. It has been demonstrated that thisprotein binds to apoptotic cells at an early stage, which raisesthe possibility that it is involved in dealing with apoptotic cellsin vivo.

References

Song, Z., et al. Atherosclerosis 211(1):90-95(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)McGeachie, M., et al. Circulation 120(24):2448-2454(2009)Lu, J., et al. Nature 456(7224):989-992(2008)Verwey, N.A., et al. Dement Geriatr Cogn Disord 26(6):522-527(2008)

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$ 80.00
Cat# BP10677b
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