|Other Names||HLA class I histocompatibility antigen, B-7 alpha chain, MHC class I antigen B*7, HLA-B, HLAB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the presentation of foreign antigens to the immune system.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
HLA-B belongs to the HLA class I heavy chain paralogues.This class I molecule is a heterodimer consisting of a heavy chainand a light chain (beta-2 microglobulin). The heavy chain isanchored in the membrane. Class I molecules play a central role inthe immune system by presenting peptides derived from theendoplasmic reticulum lumen. They are expressed in nearly allcells. The heavy chain is approximately 45 kDa and its genecontains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3encode the alpha1 and alpha2 domains, which both bind the peptide,exon 4 encodes the alpha3 domain, exon 5 encodes the transmembraneregion and exons 6 and 7 encode the cytoplasmic tail. Polymorphismswithin exon 2 and exon 3 are responsible for the peptide bindingspecificity of each class one molecule. Typing for thesepolymorphisms is routinely done for bone marrow and kidneytransplantation. Hundreds of HLA-B alleles have been described.
Parsons, M.S., et al. J. Infect. Dis. 202 SUPPL 3, S356-S360 (2010) :Brockman, M.A., et al. J. Virol. 84(22):11937-11949(2010)Noble, J.A., et al. Diabetes 59(11):2972-2979(2010)Lipponen, K., et al. Diabetes (2010) In press :Liao, Y.Q., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18(4):1055-1058(2010)
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