LYRM4 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9HD34 |
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Clone Names | 90713133 |
Gene ID | 57128 |
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Other Names | LYR motif-containing protein 4, LYRM4, C6orf149, ISD11 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LYRM4 (HGNC:21365) |
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Synonyms | C6orf149, ISD11 |
Function | Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822, PubMed:17331979). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (PubMed:19454487). |
Cellular Location | Mitochondrion. Nucleus |
Tissue Location | Reduced mRNA levels in Friedreich ataxia patients. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Henckaerts, L., et al. Clin. Gastroenterol. Hepatol. 7(9):972-980(2009)Shi, Y., et al. Hum. Mol. Genet. 18(16):3014-3025(2009)Weersma, R.K., et al. Am. J. Gastroenterol. 104(3):630-638(2009)
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