PON1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P27169 |
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Clone Names | 90713163 |
Gene ID | 5444 |
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Other Names | Serum paraoxonase/arylesterase 1, PON 1, Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, PON1, PON |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PON1 |
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Synonyms | PON |
Function | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. |
Cellular Location | Secreted, extracellular space. |
Tissue Location | Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The enzyme encoded by this gene is an arylesterase thatmainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is anorganophosphorus anticholinesterase compound that is produced invivo by oxidation of the insecticide parathion. Polymorphisms inthis gene are a risk factor in coronary artery disease. The gene isfound in a cluster of three related paraoxonase genes at 7q21.3.
References
Ergun, M.A., et al. Biochem. Genet. (2010) In press :Cagirci, G., et al. J. Heart Valve Dis. 19(4):453-458(2010)Mendonca, M.I., et al. Rev Port Cardiol 29(4):571-580(2010)Hashemi, M., et al. Genet. Mol. Res. 9(3):1735-1741(2010)Martinez, C., et al. BMC Neurol 10, 71 (2010) :
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