|Other Names||Melanin-concentrating hormone receptor 1, MCH receptor 1, MCH-R1, MCHR-1, G-protein coupled receptor 24, MCH-1R, MCH1R, MCHR, SLC-1, Somatostatin receptor-like protein, MCHR1, GPR24, SLC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart|
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The protein encoded by this gene, a member of the Gprotein-coupled receptor family 1, is an integral plasma membraneprotein which binds melanin-concentrating hormone. The encodedprotein can inhibit cAMP accumulation and stimulate intracellularcalcium flux, and is probably involved in the neuronal regulationof food consumption. Although structurally similar to somatostatinreceptors, this protein does not seem to bind somatostatin.
Miyamoto-Matsubara, M., et al. Ann. N. Y. Acad. Sci. 1200, 112-119 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Miller, C.L., et al. Schizophr. Res. 113 (2-3), 259-267 (2009) :Gavalas, N.G., et al. Exp. Dermatol. 18(5):454-463(2009)de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
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