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MCHR1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99705 |
|---|---|
| Clone Names | 90723085 |
| Gene ID | 2847 |
|---|---|
| Other Names | Melanin-concentrating hormone receptor 1, MCH receptor 1, MCH-R1, MCHR-1, G-protein coupled receptor 24, MCH-1R, MCH1R, MCHR, SLC-1, Somatostatin receptor-like protein, MCHR1, GPR24, SLC1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MCHR1 (HGNC:4479) |
|---|---|
| Synonyms | GPR24, SLC1 |
| Function | Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene, a member of the Gprotein-coupled receptor family 1, is an integral plasma membraneprotein which binds melanin-concentrating hormone. The encodedprotein can inhibit cAMP accumulation and stimulate intracellularcalcium flux, and is probably involved in the neuronal regulationof food consumption. Although structurally similar to somatostatinreceptors, this protein does not seem to bind somatostatin.
References
Miyamoto-Matsubara, M., et al. Ann. N. Y. Acad. Sci. 1200, 112-119 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Miller, C.L., et al. Schizophr. Res. 113 (2-3), 259-267 (2009) :Gavalas, N.G., et al. Exp. Dermatol. 18(5):454-463(2009)de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
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