|Other Names||Regulator of nonsense transcripts 2, Nonsense mRNA reducing factor 2, Up-frameshift suppressor 2 homolog, hUpf2, UPF2, KIAA1408, RENT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.|
|Cellular Location||Cytoplasm, perinuclear region|
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Provided below are standard protocols that you may find useful for product applications.
UPF2 is a protein that is part of apost-splicing multiprotein complex involved in both mRNA nuclearexport and mRNA surveillance. mRNA surveillance detects exportedmRNAs with truncated open reading frames and initiatesnonsense-mediated mRNA decay (NMD). When translation ends upstreamfrom the last exon-exon junction, this triggers NMD to degrademRNAs containing premature stop codons. This protein is located inthe perinuclear area. It interacts with translation release factorsand the proteins that are functional homologs of yeast Upf1p andUpf3p.
Clerici, M., et al. EMBO J. 28(15):2293-2306(2009)Cronin, S., et al. Eur. J. Hum. Genet. 17(2):213-218(2009)Woeller, C.F., et al. EMBO Rep. 9(5):446-451(2008)Chamieh, H., et al. Nat. Struct. Mol. Biol. 15(1):85-93(2008)Singh, G., et al. Mol. Cell 27(5):780-792(2007)
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