|Other Names||Folate receptor alpha, FR-alpha, Adult folate-binding protein, FBP, Folate receptor 1, Folate receptor, adult, KB cells FBP, Ovarian tumor-associated antigen MOv18, FOLR1, FOLR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane|
|Tissue Location||Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the folatereceptor family. Members of this gene family bind folic acid andits reduced derivatives, and transport 5-methyltetrahydrofolateinto cells. This gene product is a secreted protein that eitheranchors to membranes via a glycosyl-phosphatidylinositol linkage orexists in a soluble form. Mutations in this gene have beenassociated with neurodegeneration due to cerebral folate transportdeficiency. Due to the presence of two promoters, multipletranscription start sites, and alternative splicing, multipletranscript variants encoding the same protein have been found forthis gene.
Sivakumaran, S., et al. J. Steroid Biochem. Mol. Biol. 122(5):333-340(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)O'Byrne, M.R., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(8):689-694(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Elwood, P.C., et al. Biochemistry 36(6):1467-1478(1997)
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