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ARHGAP10 Antibody (Center) Blocking peptide

Synthetic peptide

     
  • SPECIFICATION
  • CITATIONS
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Product Information
Primary Accession A1A4S6
Clone Names 90819147
Peptide ID 90819147
Additional Information
Gene ID 79658
Other Names Rho GTPase-activating protein 10, GTPase regulator associated with focal adhesion kinase 2, Graf-related protein 2, Rho-type GTPase-activating protein 10, ARHGAP10, GRAF2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGAP10
Synonyms GRAF2
Function GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
Cellular Location Cytoplasm. Cytoplasm, perinuclear region. Cell membrane Note=Association to cell membrane is dependent on PH domain
Tissue Location High levels of expression in heart and skeletal muscle.
Research Areas
Citations (0)

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Background

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Azzato, E.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(4):1140-1143(2010)Lind, P.A., et al. Twin Res Hum Genet 13(1):10-29(2010)Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)

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$ 80.00
Cat# BP10695b
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