BCL10 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95999 |
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Clone Names | 90826074 |
Peptide ID | 90826074 |
Gene ID | 8915 |
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Other Names | B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, Cellular homolog of vCARMEN, cCARMEN, Cellular-E10, c-E10, Mammalian CARD-containing adapter molecule E10, mE10, BCL10, CIPER, CLAP |
Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | BCL10 |
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Synonyms | CIPER, CLAP |
Function | Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). |
Cellular Location | Cytoplasm, perinuclear region. Membrane raft. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts |
Tissue Location | Ubiquitous. |

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Background
This gene was identified by its translocation in a case ofmucosa-associated lymphoid tissue (MALT) lymphoma. The proteinencoded by this gene contains a caspase recruitment domain (CARD),and has been shown to induce apoptosis and to activate NF-kappaB.This protein is reported to interact with other CARD domaincontaining proteins including CARD9, 10, 11 and 14, which arethought to function as upstream regulators in NF-kappaB signaling.This protein is found to form a complex with MALT1, a proteinencoded by another gene known to be translocated in MALT lymphoma.MALT1 and this protein are thought to synergize in the activationof NF-kappaB, and the deregulation of either of them may contributeto the same pathogenetic process that leads to the malignancy.
References
Bhattacharyya, S., et al. Exp. Cell Res. 316(19):3317-3327(2010)Edin, S., et al. Mol. Immunol. 47 (11-12), 2057-2064 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Bhattacharyya, S., et al. J. Biol. Chem. 285(1):522-530(2010)Rehman, A.O., et al. Int J Oral Sci 1(3):105-118(2009)

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