|Other Names||BRCA1-associated ATM activator 1, BRCA1-associated protein required for ATM activation protein 1, BRAT1, BAAT1, C7orf27|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (PubMed:16452482, PubMed:22977523). Plays a role in regulating mitochondrial function and cell proliferation (PubMed:25070371). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994).|
|Cellular Location||Nucleus. Cytoplasm. Note=Present at double strand breaks (DSBs)following ionizing radiation treatment. The ubiquitinated form localizes in the nucleus in a NDFIP1-dependent manner.|
|Tissue Location||Ubiquitously expressed.|
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Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of ATM.
Aglipay, J.A., et al. J. Biol. Chem. 281(14):9710-9718(2006)
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