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EPAS1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q99814
Clone Names 90904137
Peptide ID 90904137
Additional Information
Gene ID 2034
Other Names Endothelial PAS domain-containing protein 1, EPAS-1, Basic-helix-loop-helix-PAS protein MOP2, Class E basic helix-loop-helix protein 73, bHLHe73, HIF-1-alpha-like factor, HLF, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha, Member of PAS protein 2, PAS domain-containing protein 2, EPAS1, BHLHE73, HIF2A, MOP2, PASD2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPAS1
Synonyms BHLHE73, HIF2A, MOP2, PASD2
Function Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Cellular Location Nucleus {ECO:0000250|UniProtKB:P97481, ECO:0000255|PROSITE-ProRule:PRU00981}. Nucleus speckle {ECO:0000250|UniProtKB:P97481}. Note=Colocalizes with HIF3A in the nucleus and speckles. {ECO:0000250|UniProtKB:P97481}
Tissue Location Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells
Research Areas
Citations (0)

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This gene encodes a transcription factor involved in theinduction of genes regulated by oxygen, which is induced as oxygenlevels fall. The encoded protein contains a basic-helix-loop-helixdomain protein dimerization domain as well as a domain found inproteins in signal transduction pathways which respond to oxygenlevels. Mutations in this gene are associated with erythrocytosisfamilial type 4.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Yi, X., et al. Science 329(5987):75-78(2010)Bougatef, F., et al. PLoS ONE 5 (8), E12265 (2010) :Hossein Ghaderian, S.M., et al. Pathology 42(5):446-453(2010)Mowat, F.M., et al. PLoS ONE 5 (6), E11103 (2010) :

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$ 80.00
Cat# BP10707a
(40 western blots)
Availability: In Stock
Bulk Size
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