|Other Names||55 kDa erythrocyte membrane protein, p55, Membrane protein, palmitoylated 1, MPP1, DXS552E, EMP55|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity).|
|Cellular Location||Membrane; Lipid-anchor. Cell projection, stereocilium. Note=Colocalizes with WHRN at stereocilium tip during hair cell development (By similarity) Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). Colocalizes with NF2 in non- myelin-forming Schwann cells.|
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This gene encodes the prototype of the membrane-associatedguanylate kinase (MAGUK) family proteins. MAGUKs interact with thecytoskeleton and regulate cell proliferation, signaling pathways,and intercellular junctions. The encoded protein is an extensivelypalmitoylated membrane phosphoprotein containing a PDZ domain, aSrc homology 3 (SH3) motif, and a guanylate kinase domain. Thisgene product interacts with various cytoskeletal proteins and celljunctional proteins in different tissue and cell types, and may beinvolved in the regulation of cell shape, hair cell development,neural patterning of the retina, and apico-basal polarity and tumorsuppression pathways in non-erythroid cells. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Seo, P.S., et al. Exp. Biol. Med. (Maywood) 234(3):255-262(2009)Seo, P.S., et al. Biochim. Biophys. Acta 1793(2):281-289(2009)Gosens, I., et al. Hum. Mol. Genet. 16(16):1993-2003(2007)Kusunoki, H., et al. Proteins 64(3):804-807(2006)Funke, L., et al. Annu. Rev. Biochem. 74, 219-245 (2005) :
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