|Other Names||Claudin-6, Skullin, CLDN6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity). May act as a coreceptor for HCV entry into hepatic cells.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines|
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Tight junctions represent one mode of cell-to-celladhesion in epithelial or endothelial cell sheets, formingcontinuous seals around cells and serving as a physical barrier toprevent solutes and water from passing freely through theparacellular space. These junctions are comprised of sets ofcontinuous networking strands in the outwardly facing cytoplasmicleaflet, with complementary grooves in the inwardly facingextracytoplasmic leaflet. This gene encodes a component of tightjunction strands, which is a member of the claudin family. Theprotein is an integral membrane protein and is one of the entrycofactors for hepatitis C virus. The gene methylation may beinvolved in esophageal tumorigenesis. This gene is adjacent toanother family member CLDN9 on chromosome 16.
Wu, Q., et al. Eur. J. Cancer Prev. 19(3):186-194(2010)Kleinschmidt-DeMasters, B.K., et al. Am. J. Surg. Pathol. 34(3):341-354(2010)Rendon-Huerta, E., et al. J Gastrointest Cancer 41(1):52-59(2010)Wu, Q., et al. Zhonghua Yi Xue Za Zhi 90(6):407-412(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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