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CLDN6 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P56747 |
|---|---|
| Clone Names | 90909135 |
| Gene ID | 9074 |
|---|---|
| Other Names | Claudin-6, Skullin, CLDN6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLDN6 |
|---|---|
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space. |
| Cellular Location | Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z262}. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tight junctions represent one mode of cell-to-celladhesion in epithelial or endothelial cell sheets, formingcontinuous seals around cells and serving as a physical barrier toprevent solutes and water from passing freely through theparacellular space. These junctions are comprised of sets ofcontinuous networking strands in the outwardly facing cytoplasmicleaflet, with complementary grooves in the inwardly facingextracytoplasmic leaflet. This gene encodes a component of tightjunction strands, which is a member of the claudin family. Theprotein is an integral membrane protein and is one of the entrycofactors for hepatitis C virus. The gene methylation may beinvolved in esophageal tumorigenesis. This gene is adjacent toanother family member CLDN9 on chromosome 16.
References
Wu, Q., et al. Eur. J. Cancer Prev. 19(3):186-194(2010)Kleinschmidt-DeMasters, B.K., et al. Am. J. Surg. Pathol. 34(3):341-354(2010)Rendon-Huerta, E., et al. J Gastrointest Cancer 41(1):52-59(2010)Wu, Q., et al. Zhonghua Yi Xue Za Zhi 90(6):407-412(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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