|Other Names||N-acetyltransferase ESCO2, 231-, Establishment of cohesion 1 homolog 2, ECO1 homolog 2, ESCO2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3.|
|Cellular Location||Nucleus. Chromosome|
|Tissue Location||Widely expressed in fetal tissues. In adult, it is expressed in thymus, placenta and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that may haveacetyltransferase activity and may be required for theestablishment of sister chromatid cohesion during the S phase ofmitosis. Mutations in this gene have been associated with Robertssyndrome.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Nishihara, M., et al. Biochem. Biophys. Res. Commun. 393(1):111-117(2010)Vega, H., et al. J. Med. Genet. 47(1):30-37(2010)Terret, M.E., et al. Nature 462(7270):231-234(2009)van der Lelij, P., et al. PLoS ONE 4 (9), E6936 (2009) :
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