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ETS1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P14921 |
|---|---|
| Clone Names | 91009025 |
| Gene ID | 2113 |
|---|---|
| Other Names | Protein C-ets-1, p54, ETS1, EWSR2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ETS1 |
|---|---|
| Synonyms | EWSR2 |
| Function | Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518). |
| Cellular Location | Nucleus. Cytoplasm Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. |
| Tissue Location | Highly expressed within lymphoid cells. Isoforms c- ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ETS transcriptions factors, such as ETS1, regulatenumerous genes and are involved in stem cell development, cellsenescence and death, and tumorigenesis. The conserved ETS domainwithin these proteins is a winged helix-turn-helix DNA-bindingdomain that recognizes the core consensus DNA sequence GGAA/T oftarget genes (summary by Dwyer et al., 2007 [PubMed17986575]).
References
Harris, T.A., et al. Arterioscler. Thromb. Vasc. Biol. 30(10):1990-1997(2010)He, C.F., et al. Lupus 19(10):1181-1186(2010)Russell, L., et al. Cytokine 51(3):217-226(2010)Li, T., et al. Pharm Biol 48(2):161-165(2010)Kunderfranco, P., et al. PLoS ONE 5 (5), E10547 (2010) :
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