|Other Names||Protein C-ets-1, p54, ETS1, EWSR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.|
|Cellular Location||Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27|
|Tissue Location||Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.|
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Provided below are standard protocols that you may find useful for product applications.
ETS transcriptions factors, such as ETS1, regulatenumerous genes and are involved in stem cell development, cellsenescence and death, and tumorigenesis. The conserved ETS domainwithin these proteins is a winged helix-turn-helix DNA-bindingdomain that recognizes the core consensus DNA sequence GGAA/T oftarget genes (summary by Dwyer et al., 2007 [PubMed17986575]).
Harris, T.A., et al. Arterioscler. Thromb. Vasc. Biol. 30(10):1990-1997(2010)He, C.F., et al. Lupus 19(10):1181-1186(2010)Russell, L., et al. Cytokine 51(3):217-226(2010)Li, T., et al. Pharm Biol 48(2):161-165(2010)Kunderfranco, P., et al. PLoS ONE 5 (5), E10547 (2010) :
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