|Other Names||Glutamate receptor ionotropic, NMDA 3A, GluN3A, N-methyl-D-aspartate receptor subtype 3A, NMDAR3A, NR3A, NMDAR-L, GRIN3A, KIAA1973|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity).|
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This gene encodes a subunit of the N-methyl-D-aspartate(NMDA) receptors, which belong to the superfamily ofglutamate-regulated ion channels, and function in physiological andpathological processes in the central nervous system. This subunitshows greater than 90% identity to the corresponding subunit inrat. Studies in the knockout mouse deficient in this subunitsuggest that this gene may be involved in the development ofsynaptic elements by modulating NMDA receptor activity. [providedby RefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ma, J.Z., et al. Hum. Genet. 127(5):503-512(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Liu, H.P., et al. Dement Geriatr Cogn Disord 28(6):521-527(2009)
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