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H2AFY2 Antibody (N-term) Blocking peptide

Synthetic peptide

     
  • SPECIFICATION
  • CITATIONS
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Product Information
Primary Accession Q9P0M6
Clone Names 91013091
Peptide ID 91013091
Additional Information
Gene ID 55506
Other Names Core histone macro-H2A2, Histone macroH2A2, mH2A2, H2AFY2, MACROH2A2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name H2AFY2
Synonyms MACROH2A2
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Cellular Location Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin
Research Areas
Citations (0)

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Background

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

References

Xu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):2136-2140(2010)Sporn, J.C., et al. Oncogene 28(38):3423-3428(2009)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Zhang, R., et al. Dev. Cell 8(1):19-30(2005)Deloukas, P., et al. Nature 429(6990):375-381(2004)

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$ 80.00
Cat# BP10726a
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