Register or Login
All
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Peptides   >   Blocking Peptides   >   H2AFY2 Antibody (N-term) Blocking peptide   

H2AFY2 Antibody (N-term) Blocking peptide

Synthetic peptide

     
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Primary Accession Q9P0M6
Clone Names 91013091
Peptide ID 91013091
Additional Information
Other Names Core histone macro-H2A2, Histone macroH2A2, mH2A2, H2AFY2, MACROH2A2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name H2AFY2
Synonyms MACROH2A2
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Cellular Location Nucleus Chromosome Note=Enriched in inactive X chromosome chromatin (PubMed:11331621, PubMed:11262398) and in senescence-associated heterochromatin (PubMed:15621527). EMBL; AF336304; AAK52471.1; -; mRNA EMBL; AF151534; AAF72101.1; -; mRNA EMBL; AK022776; BAB14239.1; -; mRNA EMBL; AL731540; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC016172; AAH16172.1; -; mRNA CCDS; CCDS7296.1; - RefSeq; NP_061119.1; NM_018649.2 UniGene; Hs.499953; - PDB; 2XD7; X-ray; 2.09 A; A/B/C/D=177-369 PDB; 6FY5; X-ray; 1.65 A; A/B=178-372 PDBsum; 2XD7; - PDBsum; 6FY5; - ProteinModelPortal; Q9P0M6; - SMR; Q9P0M6; - BioGrid; 120686; 120 DIP; DIP-48563N; - IntAct; Q9P0M6; 11 MINT; Q9P0M6; - STRING; 9606.ENSP00000362352; - iPTMnet; Q9P0M6; - PhosphoSitePlus; Q9P0M6; - BioMuta; H2AFY2; - DMDM; 12585260; - EPD; Q9P0M6; - MaxQB; Q9P0M6; - PaxDb; Q9P0M6; - PeptideAtlas; Q9P0M6; - PRIDE; Q9P0M6; - ProteomicsDB; 83580; - DNASU; 55506; - Ensembl; ENST00000373255; ENSP00000362352; ENSG00000099284 GeneID; 55506; - KEGG; hsa:55506; - UCSC; uc001jqm.4; human CTD; 55506; - DisGeNET; 55506; - EuPathDB; HostDB:ENSG00000099284.13; - GeneCards; H2AFY2; - H-InvDB; HIX0008890; - HGNC; HGNC:14453; H2AFY2 HPA; HPA035865; - HPA; HPA041189; - MIM; 616141; gene neXtProt; NX_Q9P0M6; - OpenTargets; ENSG00000099284; - PharmGKB; PA29118; - eggNOG; ENOG410IV3A; Eukaryota eggNOG; KOG1756; Eukaryota eggNOG; KOG2633; Eukaryota eggNOG; COG2110; LUCA eggNOG; COG5262; LUCA GeneTree; ENSGT00910000143981; - HOGENOM; HOG000234653; - HOVERGEN; HBG009342; - InParanoid; Q9P0M6; - KO; K11251; - OMA; MKVEGIV; - OrthoDB; EOG091G0XGD; - PhylomeDB; Q9P0M6; - TreeFam; TF332276; - ChiTaRS; H2AFY2; human EvolutionaryTrace; Q9P0M6; - GeneWiki; H2AFY2; - GenomeRNAi; 55506; - PRO; PR:Q9P0M6; - Proteomes; UP000005640; Chromosome 10 Bgee; ENSG00000099284; - CleanEx; HS_H2AFY2; - ExpressionAtlas; Q9P0M6; baseline and differential Genevisible; Q9P0M6; HS GO; GO:0001740; C:Barr body; IDA:MGI GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0000790; C:nuclear chromatin; IDA:UniProtKB GO; GO:0000784; C:nuclear chromosome, telomeric region; HDA:BHF-UCL GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW GO; GO:0031490; F:chromatin DNA binding; IDA:UniProtKB GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:UniProtKB GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB GO; GO:0007420; P:brain development; IMP:UniProtKB GO; GO:0006342; P:chromatin silencing; IBA:GO_Central GO; GO:0007549; P:dosage compensation; IDA:MGI GO; GO:0071169; P:establishment of protein localization to chromatin; IMP:UniProtKB GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IMP:UniProtKB GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB GO; GO:1901837; P:negative regulation of transcription of nucleolar large rRNA by RNA polymerase I; IGI:UniProtKB GO; GO:0006334; P:nucleosome assembly; IEA:InterPro GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IMP:UniProtKB CDD; cd00074; H2A; 1 CDD; cd02904; Macro_H2A_like; 1 Gene3D; 1.10.20.10; -; 1 InterPro; IPR021171; Core_histone_macro-H2A InterPro; IPR009072; Histone-fold InterPro; IPR002119; Histone_H2A InterPro; IPR007125; Histone_H2A/H2B/H3 InterPro; IPR032454; Histone_H2A_C InterPro; IPR002589; Macro_dom InterPro; IPR035796; Macro_H2A Pfam; PF00125; Histone; 1 Pfam; PF16211; Histone_H2A_C; 1 Pfam; PF01661; Macro; 1 PIRSF; PIRSF037942; Core_histone_macro-H2A; 1 PRINTS; PR00620; HISTONEH2A SMART; SM00506; A1pp; 1 SMART; SM00414; H2A; 1 SUPFAM; SSF47113; SSF47113; 1 PROSITE; PS51154; MACRO; 1 1: Evidence at protein level; 3D-structure; Chromatin regulator; Chromosome; Complete proteome; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Reference proteome; Ubl conjugation CHAIN 1 372 Core histone macro-H2A.2 /FTId=PRO_0000055320 DOMAIN 2 117 Histone H2A DOMAIN 184 370 Macro. {ECO:0000255|PROSITE- ProRule:PRU00490} COMPBIAS 118 161 Lys-rich CROSSLNK 239 239 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) STRAND 183 191 {ECO:0000244|PDB:6FY5} STRAND 196 202 {ECO:0000244|PDB:6FY5} HELIX 204 209 {ECO:0000244|PDB:6FY5} STRAND 213 219 {ECO:0000244|PDB:6FY5} HELIX 227 252 {ECO:0000244|PDB:6FY5} STRAND 260 264 {ECO:0000244|PDB:6FY5} STRAND 266 277 {ECO:0000244|PDB:6FY5} HELIX 286 302 {ECO:0000244|PDB:6FY5} TURN 303 305 {ECO:0000244|PDB:6FY5} STRAND 307 311 {ECO:0000244|PDB:6FY5} HELIX 323 339 {ECO:0000244|PDB:6FY5} STRAND 348 353 {ECO:0000244|PDB:6FY5} HELIX 356 366 {ECO:0000244|PDB:6FY5} STRAND 369 371 {ECO:0000244|PDB:6FY5} SEQUENCE 372 AA; 40058 MW; C4B35CD156031AF1 CRC64; MSGRSGKKKM SKLSRSARAG VIFPVGRLMR YLKKGTFKYR ISVGAPVYMA AVIEYLAAEI LELAGNAARD NKKARIAPRH ILLAVANDEE LNQLLKGVTI ASGGVLPRIH PELLAKKRGT KGKSETILSP PPEKRGRKAT SGKKGGKKSK AAKPRTSKKS KPKDSDKEGT SNSTSEDGPG DGFTILSSKS LVLGQKLSLT QSDISHIGSM RVEGIVHPTT AEIDLKEDIG KALEKAGGKE FLETVKELRK SQGPLEVAEA AVSQSSGLAA KFVIHCHIPQ WGSDKCEEQL EETIKNCLSA AEDKKLKSVA FPPFPSGRNC FPKQTAAQVT LKAISAHFDD SSASSLKNVY FLLFDSESIG IYVQEMAKLD AK
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to
info@abgent.com, and receive a free "I Love Antibodies" mug.

Background

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

References

Xu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):2136-2140(2010)Sporn, J.C., et al. Oncogene 28(38):3423-3428(2009)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Zhang, R., et al. Dev. Cell 8(1):19-30(2005)Deloukas, P., et al. Nature 429(6990):375-381(2004)

FeedBack
Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at tech@abgent.com.

$ 80.00
Cat# BP10726a
Size:
Quantity:
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
“Crown Flash”  50 % off on 2,500+ Crown Antibodies. PromoCode:<span class=text-red> FLASH50
Terms & Conditions