|Other Names||Heparan sulfate glucosamine 3-O-sulfotransferase 5, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5, 3-OST-5, Heparan sulfate 3-O-sulfotransferase 5, h3-OST-5, HS3ST5, 3OST5, HS3OST5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O- sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
HS3ST5 belongs to a group of heparan sulfate3-O-sulfotransferases (EC 220.127.116.11) that transfer sulfate from3-prime-phosphoadenosine 5-prime phosphosulfate (PAPS) to heparansulfate and heparin (Mochizuki et al., 2003 [PubMed12740361]).
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)Chen, J., et al. Biochim. Biophys. Acta 1725(2):190-200(2005)Duncan, M.B., et al. Biochim. Biophys. Acta 1671 (1-3), 34-43 (2004) :Mochizuki, H., et al. J. Biol. Chem. 278(29):26780-26787(2003)Xia, G., et al. J. Biol. Chem. 277(40):37912-37919(2002)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.