|Other Names||Inhibitor of Bruton tyrosine kinase, IBtk, IBTK, BTKI, KIAA1417|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation|
|Tissue Location||Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene binds to Bruton'styrosine kinase (BTK) and downregulates BTK's kinase activity. Inaddition, the encoded protein disrupts BTK-mediated calciummobilization and negatively regulates the activation of nuclearfactor-kappa-B-driven transcription.
Fiume, G., et al. Comput Biol Chem 33(6):434-439(2009)Spatuzza, C., et al. Nucleic Acids Res. 36(13):4402-4416(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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