|Other Names||Immunoglobulin superfamily member 1, IgSF1, Immunoglobulin-like domain-containing protein 1, Inhibin-binding protein, InhBP, Pituitary gland-specific factor 2, p120, IGSF1, IGDC1, KIAA0364, PGSF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||IGDC1, KIAA0364, PGSF2|
|Function||Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription.|
|Cellular Location||Isoform 1: Membrane; Multi- pass membrane protein Isoform 3: Secreted.|
|Tissue Location||Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine. Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the immunoglobulin-likedomain-containing superfamily. Proteins in this superfamily containvarying numbers of immunoglobulin-like domains and are thought toparticipate in the regulation of interactions between cells.Multiple transcript variants encoding different isoforms have beenfound for this gene.
Robakis, T., et al. J. Biol. Chem. 283(52):36369-36376(2008)Nakayama, M., et al. Genome Res. 12(11):1773-1784(2002)Tanaka, S., et al. J. Mol. Endocrinol. 28(1):33-44(2002)Gui, Y., et al. J. Clin. Endocrinol. Metab. 86(5):2104-2110(2001)Chapman, S.C., et al. Mol. Endocrinol. 15(4):668-679(2001)
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