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PRSS1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P07477 |
|---|---|
| Clone Names | 91019075 |
| Gene ID | 5644 |
|---|---|
| Other Names | Trypsin-1, Beta-trypsin, Cationic trypsinogen, Serine protease 1, Trypsin I, Alpha-trypsin chain 1, Alpha-trypsin chain 2, PRSS1, TRP1, TRY1, TRYP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PRSS1 (HGNC:9475) |
|---|---|
| Function | Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates. |
| Cellular Location | Secreted, extracellular space. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a trypsinogen, which is a member of thetrypsin family of serine proteases. This enzyme is secreted by thepancreas and cleaved to its active form in the small intestine. Itis active on peptide linkages involving the carboxyl group oflysine or arginine. Mutations in this gene are associated withhereditary pancreatitis. This gene and several other trypsinogengenes are localized to the T cell receptor beta locus on chromosome7.
References
Joergensen, M.T., et al. Am. J. Gastroenterol. 105(8):1876-1883(2010)Gasiorowska, A., et al. Dig. Dis. Sci. (2010) In press :Szmola, R., et al. J. Med. Genet. 47(5):348-350(2010)Nakanuma, S., et al. Int. J. Oncol. 36(4):793-800(2010)Johansen, D., et al. Pancreatology 10 (2-3), 229-237 (2010) :
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