|Other Names||Protein SEC13 homolog, SEC13-like protein 1, SEC13-related protein, SEC13, D3S1231E, SEC13L1, SEC13R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||D3S1231E, SEC13L1, SEC13R|
|Function||Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|
|Cellular Location||Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the SEC13family of WD-repeat proteins. It is a constituent of theendoplasmic reticulum and the nuclear pore complex. It hassimilarity to the yeast SEC13 protein, which is required forvesicle biogenesis from endoplasmic reticulum during the transportof proteins. Multiple alternatively spliced transcript variantshave been found.
Nielsen, A.L. Biochem. Biophys. Res. Commun. 388(3):571-575(2009)Townley, A.K., et al. J. Cell. Sci. 121 (PT 18), 3025-3034 (2008) :Stagg, S.M., et al. Cell 134(3):474-484(2008)Hsia, K.C., et al. Cell 131(7):1313-1326(2007)Glavy, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(10):3811-3816(2007)
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