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SEC13 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P55735 |
|---|---|
| Clone Names | 91023066 |
| Gene ID | 6396 |
|---|---|
| Other Names | Protein SEC13 homolog, SEC13-like protein 1, SEC13-related protein, SEC13, D3S1231E, SEC13L1, SEC13R |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SEC13 |
|---|---|
| Function | Functions as a component of the nuclear pore complex (NPC) and the COPII coat (PubMed:8972206). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). |
| Cellular Location | Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Lysosome membrane. Note=In interphase, localizes at both sides of the NPC. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the SEC13family of WD-repeat proteins. It is a constituent of theendoplasmic reticulum and the nuclear pore complex. It hassimilarity to the yeast SEC13 protein, which is required forvesicle biogenesis from endoplasmic reticulum during the transportof proteins. Multiple alternatively spliced transcript variantshave been found.
References
Nielsen, A.L. Biochem. Biophys. Res. Commun. 388(3):571-575(2009)Townley, A.K., et al. J. Cell. Sci. 121 (PT 18), 3025-3034 (2008) :Stagg, S.M., et al. Cell 134(3):474-484(2008)Hsia, K.C., et al. Cell 131(7):1313-1326(2007)Glavy, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(10):3811-3816(2007)
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