|Other Names||ORM1-like protein 3, ORMDL3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus|
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Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)Liu, X., et al. Nat. Genet. 42(8):658-660(2010)Halapi, E., et al. Eur. J. Hum. Genet. 18(8):902-908(2010)Dobbins, S.E., et al. Int. J. Cancer (2010) In press :McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
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