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RPH3AL Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UNE2 |
|---|---|
| Clone Names | 91102008 |
| Gene ID | 9501 |
|---|---|
| Other Names | Rab effector Noc2, No C2 domains protein, Rabphilin-3A-like protein, RPH3AL, NOC2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RPH3AL |
|---|---|
| Synonyms | NOC2 |
| Function | Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells. |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells |
| Tissue Location | Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver Also detected in epithelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene plays a direct regulatoryrole in calcium-ion-dependent exocytosis in both endocrine andexocrine cells and plays a key role in insulin secretion bypancreatic cells. This gene is likely a tumor suppressor.Alternative splicing results in multiple transcript variantsencoding distinct isoforms.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Shanmugam, C., et al. Biotech Histochem 84(2):39-45(2009)Katkoori, V.R., et al. Front. Biosci. 13, 1050-1061 (2008) :Matsumoto, M., et al. Proc. Natl. Acad. Sci. U.S.A. 101(22):8313-8318(2004)Manabe, S., et al. Biochem. Biophys. Res. Commun. 316(1):218-225(2004)
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