|Other Names||Rab effector Noc2, No C2 domains protein, Rabphilin-3A-like protein, RPH3AL, NOC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells|
|Tissue Location||Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells|
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The protein encoded by this gene plays a direct regulatoryrole in calcium-ion-dependent exocytosis in both endocrine andexocrine cells and plays a key role in insulin secretion bypancreatic cells. This gene is likely a tumor suppressor.Alternative splicing results in multiple transcript variantsencoding distinct isoforms.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Shanmugam, C., et al. Biotech Histochem 84(2):39-45(2009)Katkoori, V.R., et al. Front. Biosci. 13, 1050-1061 (2008) :Matsumoto, M., et al. Proc. Natl. Acad. Sci. U.S.A. 101(22):8313-8318(2004)Manabe, S., et al. Biochem. Biophys. Res. Commun. 316(1):218-225(2004)
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