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ARHGAP17 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q68EM7
Clone Names 91109025
Peptide ID 91109025
Additional Information
Gene ID 55114
Other Names Rho GTPase-activating protein 17, Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH-1, ARHGAP17, RICH1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RICH1
Function Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
Cellular Location Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact
Tissue Location Ubiquitously expressed. Expressed at higher level in heart and placenta.
Research Areas
Citations (0)

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RICH1 is a GTPase-activating protein (GAP). GAPs stimulatethe intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied byOMIM].


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Wells, C.D., et al. Cell 125(3):535-548(2006)Richnau, N., et al. J. Biol. Chem. 276(37):35060-35070(2001)Reczek, D., et al. J. Cell Biol. 153(1):191-206(2001)

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$ 80.00
Cat# BP10759a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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