|Other Names||Ornithine decarboxylase antizyme 2, AZ2, ODC-Az 2, OAZ2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.|
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Ornithine decarboxylase catalyzes the conversion ofornithine to putrescine in the first and apparently rate-limitingstep in polyamine biosynthesis. The ornithine decarboxylaseantizymes play a role in the regulation of polyamine synthesis bybinding to and inhibiting ornithine decarboxylase. Antizymeexpression is auto-regulated by polyamine-enhanced translationalframeshifting. The antizyme encoded by this gene inhibits ornithinedecarboxylase but does not accelerate its degradation. [provided byRefSeq].
Geerts, D., et al. Int. J. Cancer 126(9):2012-2024(2010)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Mangold, U., et al. Biochem. J. 385 (PT 1), 21-28 (2005) :Chen, H., et al. J. Biol. Chem. 277(48):45957-45961(2002)Coffino, P. Proc. Natl. Acad. Sci. U.S.A. 97(9):4421-4423(2000)
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