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CLPX Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O76031 |
|---|---|
| Clone Names | 91113164 |
| Gene ID | 10845 |
|---|---|
| Other Names | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial, CLPX |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLPX |
|---|---|
| Function | ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP (PubMed:28874591). Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5- aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591). Important for efficient erythropoiesis through up- regulation of heme biosynthesis (PubMed:25957689, PubMed:28874591). |
| Cellular Location | Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid |
| Tissue Location | Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP (By similarity).
References
Martin, A., et al. Mol. Cell 29(4):441-450(2008)Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Kang, S.G., et al. J. Biol. Chem. 280(42):35424-35432(2005)Kang, S.G., et al. J. Biol. Chem. 277(23):21095-21102(2002)
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