|Other Names||Sperm acrosome membrane-associated protein 1, Sperm acrosomal membrane-associated protein 32, SPACA1, SAMP32|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in sperm-egg fusion.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Testis specific. At the equatorial segment and the inner acrosomal membrane of capacitated sperm|
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The correlation of anti-sperm antibodies with cases ofunexplained infertility implicates a role for these antibodies inblocking fertilization. Improved diagnosis and treatment ofimmunologic infertility, as well as identification of proteins fortargeted contraception, are dependent on the identification andcharacterization of relevant sperm antigens. The protein expressedby this gene is recognized by anti-sperm antibodies from infertilemales. Furthermore, antibodies generated against the recombinantprotein block in vitro fertilization. This protein localizes to theacrosomal membrane of spermatids and mature spermatozoa where it isthought to play a role in acrosomal morphogenesis and in sperm-eggbinding and fusion, respectively.
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) :Vasan, R.S., et al. BMC Med. Genet. 8 SUPPL 1, S2 (2007) :Mungall, A.J., et al. Nature 425(6960):805-811(2003)Hao, Z., et al. Biol. Reprod. 66(3):735-744(2002)
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