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SACA1 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9HBV2
Clone Names 91119262
Peptide ID 91119262
Additional Information
Other Names Sperm acrosome membrane-associated protein 1, Sperm acrosomal membrane-associated protein 32, SPACA1, SAMP32
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPACA1
Synonyms SAMP32
Function May be involved in sperm-egg fusion.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Testis specific. At the equatorial segment and the inner acrosomal membrane of capacitated sperm EMBL; AF203447; AAG31422.1; -; mRNA EMBL; AL136096; CAI19915.1; -; Genomic_DNA EMBL; BC029488; AAH29488.1; -; mRNA CCDS; CCDS5014.1; - RefSeq; NP_112222.1; NM_030960.2 UniGene; Hs.161241; - ProteinModelPortal; Q9HBV2; - SMR; Q9HBV2; - BioGrid; 123591; 65 STRING; 9606.ENSP00000237201; - iPTMnet; Q9HBV2; - PhosphoSitePlus; Q9HBV2; - BioMuta; SPACA1; - DMDM; 74752784; - PaxDb; Q9HBV2; - PeptideAtlas; Q9HBV2; - PRIDE; Q9HBV2; - Ensembl; ENST00000237201; ENSP00000237201; ENSG00000118434 GeneID; 81833; - KEGG; hsa:81833; - UCSC; uc003pmn.3; human CTD; 81833; - DisGeNET; 81833; - GeneCards; SPACA1; - HGNC; HGNC:14967; SPACA1 HPA; HPA026744; - HPA; HPA043297; - MIM; 612739; gene neXtProt; NX_Q9HBV2; - OpenTargets; ENSG00000118434; - PharmGKB; PA37943; - eggNOG; ENOG410IFV6; Eukaryota eggNOG; ENOG410YPX9; LUCA GeneTree; ENSGT00390000004211; - HOGENOM; HOG000049221; - HOVERGEN; HBG080320; - InParanoid; Q9HBV2; - OMA; WGAKAST; - OrthoDB; EOG091G0M9J; - PhylomeDB; Q9HBV2; - TreeFam; TF336918; - BioCyc; ZFISH:ENSG00000118434-MONOMER; - GenomeRNAi; 81833; - PRO; PR:Q9HBV2; - Proteomes; UP000005640; Chromosome 6 Bgee; ENSG00000118434; - CleanEx; HS_SPACA1; - Genevisible; Q9HBV2; HS GO; GO:0002080; C:acrosomal membrane; IBA:GO_Central GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0001675; P:acrosome assembly; IBA:GO_Central 1: Evidence at protein level; Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix SIGNAL 1 29 CHAIN 30 294 Sperm acrosome membrane-associated protein 1 /FTId=PRO_0000248152 TOPO_DOM 30 221 Extracellular. TRANSMEM 222 242 Helical. TOPO_DOM 243 294 Cytoplasmic. MOD_RES 256 256 Phosphoserine MOD_RES 290 290 Phosphoserine {ECO:0000250|UniProtKB:Q9DA48} CARBOHYD 31 31 N-linked (GlcNAc...). VARIANT 237 237 L -> S (in dbSNP:rs2276089) /FTId=VAR_027258 SEQUENCE 294 AA; 32143 MW; 60DB3107E1B03D12 CRC64; MSPRGTGCSA GLLMTVGWLL LAGLQSARGT NVTAAVQDAG LAHEGEGEEE TENNDSETAE NYAPPETEDV SNRNVVKEVE FGMCTVTCGI GVREVILTNG CPGGESKCVV RVEECRGPTD CGWGKPISES LESVRLACIH TSPLNRFKYM WKLLRQDQQS IILVNDSAIL EVRKESHPLA FECDTLDNNE IVATIKFTVY TSSELQMRRS SLPATDAALI FVLTIGVIIC VFIIFLLIFI IINWAAVKAF WGAKASTPEV QSEQSSVRYK DSTSLDQLPT EMPGEDDALS EWNE
Research Areas
Citations (0)

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Background

The correlation of anti-sperm antibodies with cases ofunexplained infertility implicates a role for these antibodies inblocking fertilization. Improved diagnosis and treatment ofimmunologic infertility, as well as identification of proteins fortargeted contraception, are dependent on the identification andcharacterization of relevant sperm antigens. The protein expressedby this gene is recognized by anti-sperm antibodies from infertilemales. Furthermore, antibodies generated against the recombinantprotein block in vitro fertilization. This protein localizes to theacrosomal membrane of spermatids and mature spermatozoa where it isthought to play a role in acrosomal morphogenesis and in sperm-eggbinding and fusion, respectively.

References

Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) :Vasan, R.S., et al. BMC Med. Genet. 8 SUPPL 1, S2 (2007) :Mungall, A.J., et al. Nature 425(6960):805-811(2003)Hao, Z., et al. Biol. Reprod. 66(3):735-744(2002)

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$ 80.00
Cat# BP10775a
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