|Other Names||Phospholipid-transporting ATPase ID, ATPase class I type 8B member 2, P4-ATPase flippase complex alpha subunit ATP8B2, ATP8B2, ATPID, KIAA1137|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=TMEM30A, but not TMEM30B, is required for its export from endoplasmic reticulum to the plasma membrane|
|Tissue Location||Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the family ofP-type cation transport ATPases, and to the subfamily ofaminophospholipid-transporting ATPases. The aminophospholipidtranslocases transport phosphatidylserine andphosphatidylethanolamine from one side of a bilayer to another.Alternatively spliced transcript variants encoding differentisoforms have been identified.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Harris, M.J., et al. Biochim. Biophys. Acta 1633(2):127-131(2003)Halleck, M.S., et al. Physiol. Genomics 1(3):139-150(1999)
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