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DPEP3 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H4B8 |
|---|---|
| Clone Names | 91201048 |
| Gene ID | 64180 |
|---|---|
| Other Names | Dipeptidase 3, DPEP3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DPEP3 |
|---|---|
| Function | Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (PubMed:32325220). The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance (PubMed:32325220). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9DA79}; Lipid- anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9DA79} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a membrane-bound glycoprotein from thefamily of dipeptidases involved in hydrolytic metabolism of variousdipeptides, including penem and carbapenem beta-lactam antibiotics.This gene is located on chromosome 16 in a cluster with anothermember of this family. Alternatively spliced transcript variantsthat encode different isoforms have been found for this gene.
References
Sabatti, C., et al. Nat. Genet. 41(1):35-46(2009)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Habib, G.M., et al. FASEB J. 17(10):1313-1315(2003)
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