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SYNCI Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H7C4
Clone Names 91201105
Additional Information
Gene ID 81493
Other Names Syncoilin, Syncoilin intermediate filament 1, Syncoilin-1, SYNC, SYNC1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNC
Synonyms SYNC1
Function Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.
Cellular Location Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9EPM5}. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity) {ECO:0000250|UniProtKB:Q9EPM5}
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the intermediate filamentfamily which contains an N-terminal head domain, followed by acentral coiled-coil region and a short C-terminal tail. The proteinis highly expressed in skeletal and cardiac muscle. The proteinlinks the dystrophin associated protein complex (DAPC) to desminfilaments in muscle and may have a structural role in striatedmuscle. Multiple transcript variants encoding different isoformshave been found for this gene.

References

Wakayama, Y., et al. Int. J. Neurosci. 120(2):144-149(2010)Jordanova, A., et al. Nat. Genet. 38(2):197-202(2006)Brown, S.C., et al. Muscle Nerve 32(6):715-725(2005)Poon, E., et al. J. Biol. Chem. 277(5):3433-3439(2002)Newey, S.E., et al. J. Biol. Chem. 276(9):6645-6655(2001)

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$ 277.78
Cat# BP10803a
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