SYNCI Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H7C4 |
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Clone Names | 91201105 |
Gene ID | 81493 |
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Other Names | Syncoilin, Syncoilin intermediate filament 1, Syncoilin-1, SYNC, SYNC1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SYNC |
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Synonyms | SYNC1 |
Function | Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. |
Cellular Location | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9EPM5}. Note=In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity) {ECO:0000250|UniProtKB:Q9EPM5} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the intermediate filamentfamily which contains an N-terminal head domain, followed by acentral coiled-coil region and a short C-terminal tail. The proteinis highly expressed in skeletal and cardiac muscle. The proteinlinks the dystrophin associated protein complex (DAPC) to desminfilaments in muscle and may have a structural role in striatedmuscle. Multiple transcript variants encoding different isoformshave been found for this gene.
References
Wakayama, Y., et al. Int. J. Neurosci. 120(2):144-149(2010)Jordanova, A., et al. Nat. Genet. 38(2):197-202(2006)Brown, S.C., et al. Muscle Nerve 32(6):715-725(2005)Poon, E., et al. J. Biol. Chem. 277(5):3433-3439(2002)Newey, S.E., et al. J. Biol. Chem. 276(9):6645-6655(2001)
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