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AWAT2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6E213
Clone Names 91208206
Additional Information
Gene ID 158835
Other Names Acyl-CoA wax alcohol acyltransferase 2, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, Diacylglycerol O-acyltransferase 2-like protein 4, Diacylglycerol O-acyltransferase candidate 4, hDC4, Long-chain-alcohol O-fatty-acyltransferase 2, Multifunctional O-acyltransferase, Wax synthase, hWS, AWAT2, DC4, DGAT2L4, MFAT, WS
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AWAT2
Synonyms DC4, DGAT2L4, MFAT {ECO:0000303|PubMed:1
Function Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038). Also possesses acyl- CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis- specific retinyl ester synthesis (PubMed:16106050, PubMed:24799687). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis- retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687).
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6E1M8}; Multi-pass membrane protein
Tissue Location Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas
Research Areas
Citations (0)
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Background

This gene encodes an enzyme belonging to thediacylglycerol acyltransferase family. This enzyme produces waxesters by the esterification of long chain (or wax) alcohols withacyl-CoA-derived fatty acids. It functions in lipid metabolism inthe skin, mostly in undifferentiated peripheral sebocytes. Thisenzyme may also have acyl-CoA:retinol acyltransferase activities,where it catalyzes the synthesis of diacylglycerols and retinylesters.

References

Holmes, R.S. Comp. Biochem. Physiol. Part D Genomics Proteomics 5(1):45-54(2010)Yen, C.L., et al. J. Lipid Res. 46(11):2388-2397(2005)Turkish, A.R., et al. J. Biol. Chem. 280(15):14755-14764(2005)Cheng, J.B., et al. J. Biol. Chem. 279(36):37798-37807(2004)Winter, A., et al. Cytogenet. Genome Res. 102 (1-4), 42-47 (2003) :

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$ 277.78
Cat# BP10826b
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