|Other Names||Acyl-CoA wax alcohol acyltransferase 2, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, Diacylglycerol O-acyltransferase 2-like protein 4, Diacylglycerol O-acyltransferase candidate 4, hDC4, Long-chain-alcohol O-fatty-acyltransferase 2, Multifunctional O-acyltransferase, Wax synthase, hWS, AWAT2, DC4, DGAT2L4, MFAT, WS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DC4, DGAT2L4, MFAT, WS|
|Function||Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas.|
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This gene encodes an enzyme belonging to thediacylglycerol acyltransferase family. This enzyme produces waxesters by the esterification of long chain (or wax) alcohols withacyl-CoA-derived fatty acids. It functions in lipid metabolism inthe skin, mostly in undifferentiated peripheral sebocytes. Thisenzyme may also have acyl-CoA:retinol acyltransferase activities,where it catalyzes the synthesis of diacylglycerols and retinylesters.
Holmes, R.S. Comp. Biochem. Physiol. Part D Genomics Proteomics 5(1):45-54(2010)Yen, C.L., et al. J. Lipid Res. 46(11):2388-2397(2005)Turkish, A.R., et al. J. Biol. Chem. 280(15):14755-14764(2005)Cheng, J.B., et al. J. Biol. Chem. 279(36):37798-37807(2004)Winter, A., et al. Cytogenet. Genome Res. 102 (1-4), 42-47 (2003) :
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