AWAT2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6E213 |
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Clone Names | 91208206 |
Gene ID | 158835 |
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Other Names | Acyl-CoA wax alcohol acyltransferase 2, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, Diacylglycerol O-acyltransferase 2-like protein 4, Diacylglycerol O-acyltransferase candidate 4, hDC4, Long-chain-alcohol O-fatty-acyltransferase 2, Multifunctional O-acyltransferase, Wax synthase, hWS, AWAT2, DC4, DGAT2L4, MFAT, WS |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AWAT2 |
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Synonyms | DC4, DGAT2L4, MFAT {ECO:0000303|PubMed:1 |
Function | Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038). Also possesses acyl- CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis- specific retinyl ester synthesis (PubMed:16106050, PubMed:24799687). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis- retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6E1M8}; Multi-pass membrane protein |
Tissue Location | Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme belonging to thediacylglycerol acyltransferase family. This enzyme produces waxesters by the esterification of long chain (or wax) alcohols withacyl-CoA-derived fatty acids. It functions in lipid metabolism inthe skin, mostly in undifferentiated peripheral sebocytes. Thisenzyme may also have acyl-CoA:retinol acyltransferase activities,where it catalyzes the synthesis of diacylglycerols and retinylesters.
References
Holmes, R.S. Comp. Biochem. Physiol. Part D Genomics Proteomics 5(1):45-54(2010)Yen, C.L., et al. J. Lipid Res. 46(11):2388-2397(2005)Turkish, A.R., et al. J. Biol. Chem. 280(15):14755-14764(2005)Cheng, J.B., et al. J. Biol. Chem. 279(36):37798-37807(2004)Winter, A., et al. Cytogenet. Genome Res. 102 (1-4), 42-47 (2003) :
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