|Other Names||Variable charge X-linked protein 1, Variable charge protein on X with ten repeats, VCX-10r, Variably charged protein X-B1, VCX-B1, VCX, VCX1, VCX10R, VCXB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||VCX1, VCX10R, VCXB1|
|Function||May mediate a process in spermatogenesis or may play a role in sex ratio distortion.|
|Tissue Location||Expressed exclusively in testis.|
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This gene belongs to the VCX/Y gene family, which hasmultiple members on both X and Y chromosomes, and all are expressedexclusively in male germ cells. The X-linked members are clusteredon chromosome Xp22 and Y-linked members are two identical copies ofthe gene within a palindromic region on Yq11. The family membersshare a high degree of sequence identity, with the exception that a30-bp unit is tandemly repeated in X-linked members but occurs onlyonce in Y-linked members. The VCX gene cluster is polymorphic interms of copy number; different individuals may have a differentnumber of VCX genes. VCX/Y genes encode small and highly chargedproteins of unknown function. The presence of a putative bipartitenuclear localization signal suggests that VCX/Y members are nuclearproteins. This gene contains 10 repeats of the 30-bp unit.
Hansen, M.A., et al. Mol. Reprod. Dev. 75(2):219-229(2008)Sy, S.M., et al. Lung Cancer 41(1):91-99(2003)Zou, S.W., et al. Cell Res. 13(3):171-177(2003)Fukami, M., et al. Am. J. Hum. Genet. 67(3):563-573(2000)Lahn, B.T., et al. Hum. Mol. Genet. 9(2):311-319(2000)
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