|Other Names||Transmembrane anterior posterior transformation protein 1 homolog, Cytomegalovirus partial fusion receptor, TAPT1, CMVFR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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This gene encodes a highly conserved, putativetransmembrane protein. A mutation in the mouse ortholog of thisgene results in homeotic, posterior-to-anterior transformations ofthe axial skeleton which are similar to the phenotype of mousehomeobox C8 gene mutants. This gene is proposed to functiondownstream of homeobox C8 to transduce extracellular patterninginformation during axial skeleton development. An alternativelyspliced transcript variant encoding a substantially differentisoform has been described, but its biological validity has notbeen determined.
Howell, G.R., et al. Genetics 175(2):699-707(2007)Baldwin, B.R., et al. J. Gen. Virol. 81 (PT 1), 27-35 (2000) :Baldwin, B.R., et al. Biochem. Biophys. Res. Commun. 219(2):668-673(1996)
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