|Other Names||Mitochondrial inner membrane protease subunit 1, 3421-, IMP1-like protein, IMMP1L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|
|Cellular Location||Mitochondrion inner membrane|
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Provided below are standard protocols that you may find useful for product applications.
The mitochondrial inner membrane peptidase (IMP) complexgenerates mature, active proteins in the mitochondrialintermembrane space by proteolytically removing the mitochondrialtargeting presequence of nuclear-encoded proteins. IMP1 and IMP2(IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex(Burri et al., 2005 [PubMed 15814844]).
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Taylor, T.D., et al. Nature 440(7083):497-500(2006)Burri, L., et al. Mol. Biol. Cell 16(6):2926-2933(2005)
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