|Other Names||Arpin, Arp2/3 inhibition protein, ARPIN, C15orf38|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.|
|Cellular Location||Cell projection, lamellipodium. Note=Colocalized with the WAVE complex at lamelliupodium tip.|
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Provided below are standard protocols that you may find useful for product applications.
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)
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