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C15orf38 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q7Z6K5 |
|---|---|
| Clone Names | 91218282 |
| Gene ID | 348110 |
|---|---|
| Other Names | Arpin, Arp2/3 inhibition protein, ARPIN, C15orf38 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ARPIN |
|---|---|
| Synonyms | C15orf38 |
| Function | Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. |
| Cellular Location | Cell projection, lamellipodium. Note=Colocalized with the WAVE complex at lamelliupodium tip |
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Provided below are standard protocols that you may find useful for product applications.
References
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)
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