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ENT1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q99808
Clone Names 5121271
Peptide ID 5121271
Additional Information
Gene ID 2030
Other Names Equilibrative nucleoside transporter 1, Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter, Equilibrative NBMPR-sensitive nucleoside transporter, Nucleoside transporter, es-type, Solute carrier family 29 member 1, SLC29A1, ENT1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1086c was selected from the Center region of human ENT1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC29A1
Synonyms ENT1
Function Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
Cellular Location Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Predominantly localized in the basolateral membrane in polarized MDCK cells
Tissue Location Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen
Research Areas
Citations (0)

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ENT1 is a member of the equilibrative nucleoside transporter family. It is a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies.


Bone,D.B.,Am. J. Physiol. Heart Circ. Physiol. 293 (6), H3325-H3332 (2007)Damaraju,V.L., Am. J. Physiol. Renal Physiol. 293 (1), F200-F211 (2007)Abdulla,P.,Nucleosides Nucleotides Nucleic Acids 26 (1), 99-110 (2007)Sundaram,M., J. Biol. Chem. 276 (48), 45270-45275 (2001)

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$ 80.00
Cat# BP1086c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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